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Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case
Cara Tomas1, Andreas Finkelmeyer1,2, Tim Hodgson2
1Institute of Cellular Medicine, Newcastle University, Newcastle, Newcastle upon Tyne, UK.
Open Heart
|January 19, 2018
Summary
Brain natriuretic peptide (BNP) levels are higher in chronic fatigue syndrome (CFS) patients and correlate with reduced cardiac volumes. These findings suggest cardiac involvement in CFS, independent of deconditioning.
Area of Science:
- Cardiology
- Biomarkers
- Chronic Fatigue Syndrome Research
Background:
- Chronic fatigue syndrome (CFS) is increasingly associated with cardiac abnormalities.
- Brain natriuretic peptide (BNP) is a key biomarker for cardiac stress and dysfunction.
Purpose of the Study:
- To investigate brain natriuretic peptide (BNP) levels in patients with chronic fatigue syndrome (CFS).
- To determine the association between BNP levels and cardiac abnormalities in CFS.
Main Methods:
- Cardiac magnetic resonance imaging (CMR) was performed on CFS patients and matched controls.
- Plasma BNP levels were measured using enzyme immunoassay in 42 CFS patients and 10 controls.
Main Results:
- BNP levels were significantly elevated in the CFS cohort compared to controls (P=0.013).
- Higher BNP levels (>400 pg/mL) were associated with significantly lower end-diastolic and end-systolic cardiac volumes (P=0.05).
- No correlation was found between fatigue severity, disease duration, and BNP levels, suggesting findings are not due to deconditioning.
Conclusions:
- This study confirms a link between reduced cardiac volumes and elevated BNP in CFS.
- The lack of correlation with disease duration indicates that cardiac changes may not be solely due to deconditioning.
- Further research is warranted to explore BNP's potential role in stratifying CFS patients for targeted therapies.
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