Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review

Area of Science:

• Dermatology and Surgical Oncology
• Analytical Chemistry and Spectroscopy

Background:

• Mohs micrographic surgery is a precise technique for excising skin tumors, layer by layer, with microscopic examination to ensure complete removal.
• A key challenge in Mohs surgery is accurately determining tumor depth, especially when margins are clear horizontally but positive at depth, leading to potential excessive tissue removal or incomplete treatment.

Purpose of the Study:

• To introduce and evaluate the use of laser-induced breakdown spectroscopy (LIBS) for precise depth profiling in Mohs micrographic surgery.
• To address the limitations of current methods in defining tumor depth during Mohs surgery, aiming to optimize tissue preservation and procedural efficiency.

Main Methods:

• Application of laser-induced breakdown spectroscopy (LIBS) for in-situ depth profiling of excised tissue during Mohs micrographic surgery.
• Utilizing LIBS to precisely determine the depth of tumor involvement, guiding subsequent surgical interventions.

Main Results:

• LIBS enables accurate depth profiling, allowing for precise identification of tumor boundaries at depth.
• This technique prevents unnecessary removal of healthy tissue and reduces the time spent on microscopic examination.
• Improved accuracy in defining depth can lead to more conservative excisions while ensuring tumor-free margins.

Conclusions:

• Laser-induced breakdown spectroscopy (LIBS) is a promising tool for enhancing the precision and efficiency of Mohs micrographic surgery.
• Implementing LIBS can overcome current challenges in depth determination, leading to better patient outcomes and reduced healthcare costs.