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Related Experiment Video

Updated: Feb 15, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

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Unilateral Multifocal Choroidal Melanoma.

Debarshi Mustafi1, Bertil Damato2, Jesse L Berry1

  • 1Department of Ophthalmology, USC Roski Eye Institute and Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Ocular Oncology and Pathology
|January 19, 2018
PubMed
Summary
This summary is machine-generated.

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In vivo elastography of the human retina using light-evoked intrinsic actuation.

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This study details a rare case of multifocal choroidal melanoma in one eye, with the second melanoma developing 20 years after the first. Both choroidal melanomas were successfully treated with proton beam therapy.

Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Choroidal melanoma is a rare intraocular malignancy.
  • Multifocal choroidal melanoma in the same eye is exceptionally uncommon.
  • Distinguishing between choroidal nevus and melanoma can be challenging.

Purpose of the Study:

  • To report a unique case of sequential multifocal choroidal melanoma.
  • To describe the clinical course and management of a delayed secondary choroidal melanoma.
  • To highlight imaging findings in the progression of a choroidal lesion.

Main Methods:

  • Case report of a 57-year-old male with sequential choroidal melanomas.
  • Review of clinical history, surveillance imaging, and treatment modalities.
  • Detailed analysis of radiographic and imaging findings (e.g., ultrasound, OCT).
Keywords:
Choroidal melanomaMelanomaMultifocal melanomaOptical coherence tomography angiographyProton beam radiotherapyTumor recurrence

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Main Results:

  • Initial choroidal melanoma treated with transpupillary thermotherapy and proton beam therapy due to recurrence.
  • A second distinct choroidal lesion, initially presumed nevus, transformed into melanoma over 20 years.
  • Both choroidal melanomas were managed with globe-sparing proton beam therapy.

Conclusions:

  • Multifocal choroidal melanoma can present sequentially in the same eye over extended periods.
  • Close surveillance is crucial for detecting malignant transformation of indeterminate choroidal lesions.
  • Proton beam therapy is an effective globe-salvaging treatment for recurrent and secondary choroidal melanomas.