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Genistein as a Potential Anticancer Agent Against Head and Neck Squamous Cell Carcinoma

Fatima Ardito1, Giovanni Di Gioia1, Mario Roberto Pellegrino1

  • 1Department of Clinical and Experimental Medicine, Foggia University, Foggia, Italy.

Current Topics in Medicinal Chemistry
|January 19, 2018
PubMed

Insights

Genistein, a natural nutraceutical, shows promise in fighting cancer by inhibiting tumor cell growth. This review explores its potential as a novel therapy for head and neck squamous cell cancer (HNSCC).

Area of Science:

  • Nutritional science
  • Oncology
  • Pharmacology

Background:

  • Nutraceuticals are increasingly recognized for their protective effects against chronic diseases, including cancer.
  • Genistein, a soy isoflavone, possesses known anticancer properties and is traditionally used in Asian medicine.
  • Current treatments for head and neck squamous cell cancer (HNSCC) have limited efficacy, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review the anticancer therapeutic potential of genistein.
  • To examine in vitro and in vivo studies investigating genistein's role in HNSCC treatment.

Main Methods:

  • Literature review of scientific studies on genistein and HNSCC.
  • Analysis of in vitro (cell-based) and in vivo (animal model) research data.

Main Results:

  • Genistein demonstrates inhibitory effects on tumor cell adhesion and proliferation.
  • Studies suggest genistein may counteract carcinogenic actions.
  • Evidence indicates genistein's potential efficacy against HNSCC.

Conclusions:

  • Genistein exhibits significant anticancer properties relevant to HNSCC.
  • Further research and clinical trials are warranted to establish genistein as a viable HNSCC treatment.
  • Genistein represents a promising nutraceutical candidate for HNSCC therapy.
Keywords:
GenisteinHNSCCIsoflavoneNutraceuticalsOSCCTherapy.

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