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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
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Chuzhen Therapy as a Non-Invasive Traditional Chinese Therapy for Neck Pain
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Antithrombotic Therapy After TAVR.

Tobias Geisler1, Michal Droppa1, Karin Muller1

  • 1Medizinische Klinik III, Department Cardiology and Cardiovascular Disease, German Heart Competence Centre, University Hospital Tubingen, Otfried-Muller-Straße 10, 72076 Tubingen, Germany.

Current Vascular Pharmacology
|January 19, 2018
PubMed
Summary

Transcatheter Aortic Valve Replacement (TAVR) patients face stroke risks. Current dual antiplatelet therapy lacks strong evidence, prompting research into anticoagulants like NOACs for better outcomes.

Keywords:
Antithrombotic TherapyDAPTNOACSVTTAVRstroke.

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Area of Science:

  • Cardiology
  • Neurology
  • Vascular Surgery

Background:

  • Transcatheter Aortic Valve Replacement (TAVR) is increasingly used for severe aortic stenosis, especially in high-risk patients.
  • Cerebral embolism is a significant concern impacting prognosis and quality of life after TAVR.
  • Current empiric antithrombotic therapy (Dual Antiplatelet Therapy - DAPT) lacks robust evidence regarding optimal choice and duration.

Purpose of the Study:

  • To review evidence on stroke risk in TAVR patients.
  • To evaluate the current and future role of antithrombotic therapy after TAVR.
  • To explore the potential of novel anticoagulants in TAVR patients.

Main Methods:

  • Review of existing literature on TAVR, stroke risk, and antithrombotic strategies.
  • Analysis of current guidelines and emerging research on antithrombotic treatments.
  • Discussion of ongoing clinical trials investigating Non-Vitamin K Oral Anticoagulants (NOACs).

Main Results:

  • The optimal antithrombotic regimen post-TAVR remains uncertain.
  • Dual Antiplatelet Therapy (DAPT) is standard but lacks randomized trial support.
  • Undetected atrial fibrillation is common in TAVR patients, suggesting a role for anticoagulation.

Conclusions:

  • Further research, including randomized trials, is needed to establish optimal antithrombotic therapy post-TAVR.
  • Non-Vitamin K Oral Anticoagulants (NOACs) show promise, particularly in patients with atrial fibrillation.
  • Balancing stroke prevention with bleeding risk is crucial for TAVR patient management.