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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

456
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

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Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
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Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
225
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

343
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
343
Induced-fit Model01:13

Induced-fit Model

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Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Clozapine-induced myocarditis.

Tanuka Datta1, Allen J Solomon2

  • 1Department of Internal Medicine, The George Washington University, Washington DC 20037, USA.

Oxford Medical Case Reports
|January 19, 2018
PubMed
Summary
This summary is machine-generated.

Clozapine, an antipsychotic for treatment-resistant schizophrenia, can cause myocarditis. Early recognition and drug discontinuation are crucial for full cardiac recovery and preventing severe outcomes.

Keywords:
CardiotoxicityClozapineMyocarditisTreatment Resistant Schizophrenia

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Area of Science:

  • Cardiology
  • Psychiatry
  • Pharmacology

Background:

  • Clozapine is an atypical antipsychotic approved for treatment-resistant schizophrenia.
  • It is associated with agranulocytosis and rare cardiovascular risks, including myocarditis.

Observation:

  • A patient presented with chest pain, ST elevations, and elevated troponin, mimicking acute myocardial infarction.
  • Cardiac imaging showed reduced left ventricular function, but coronary angiography revealed no obstructive coronary artery disease.

Findings:

  • The patient's presentation and diagnostic findings were consistent with Clozapine-induced myocarditis.
  • Discontinuation of Clozapine and supportive care led to complete recovery of systolic left ventricular function.

Implications:

  • Cardiologists must be aware of Clozapine-induced myocarditis presentation, diagnosis, and management in psychiatric patients.
  • Prompt recognition and intervention are vital to mitigate cardiovascular mortality risk associated with Clozapine.