Related Experiment Video
Updated: Feb 15, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
Continuous deacetylation of cephalosporins
1Pharmaceutical Division, CIBA-GEIGY Limited, CH-4002 Basel, Switzerland.
Abstract:
Continuous deacetylation of cephalosporin C, 7-aminocephalosporanic acid, and of 2-methoxyethyl acetate in packed beds of an immobilized esterase is described by simple empirical equations relating conversion to space velocity and temperature. The choice of process conditions is discussed in relation to the effects of temperature on column efficiency, column life, growth of microbial contaminants, and the rates of thermal decomposition of the substrates. At the preferred temperature of 10°C columns were operated continuously for one month with only small losses in efficiency.
Related Concept Videos
Continuing Care
Continuity of a Function
Continuity Equation
The mass flow rate is expressed as:
Continuity Equation
Equation of Continuity
Properties of Continuous Functions

