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Updated: Feb 15, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Rewiring Chemical Networks Based on Dynamic Dithioacetal and Disulfide Bonds
A Gastón Orrillo1, Agustina La-Venia2, Andrea M Escalante1
1Instituto de Investigaciones para el Descubrimiento de, Fármacos de Rosario (UNR-CONICET), OcampoyEsmeralda, 2000, Rosario, Argentina.
Abstract:
The control of the connectivity between nodes of synthetic networks is still largely unexplored. To address this point we take advantage of a simple dynamic chemical system with two exchange levels that are mutually connected and can be activated simultaneously or sequentially. Dithioacetals and disulfides can be exchanged simultaneously under UV light in the presence of a sensitizer. Crossover reactions between both exchange processes produce a fully connected chemical network. On the other hand, the use of acid, base or UV light connects different nodes allowing network rewiring.
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