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Updated: Feb 15, 2026

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
Minimally Invasive Management of Severe Aortoiliac Occlusive Disease
Luigi Pascarella1, Maen Aboul Hosn2
11 Division of Vascular Surgery, University of North Carolina , Chapel Hill, North Carolina.
Insights
Minimally invasive strategies for advanced aortoiliac disease show promise, but evidence is limited. Endovascular therapies offer benefits for high-risk patients, while aortobifemoral bypass remains optimal for select individuals.
Area of Science:
- Vascular Surgery
- Minimally Invasive Procedures
- Aortoiliac Disease Treatment
Background:
- Peripheral arterial disease (PAD) affects millions, with TASC II C and D lesions often requiring intervention.
- Aortobifemoral bypass (ABF) is the traditional gold standard for aortoiliac occlusive disease (AIOD).
- ABF offers high long-term patency rates but is invasive.
Purpose of the Study:
- To review minimally invasive strategies for TASC II C and D aortoiliac disease.
- To compare endovascular therapies and minimally invasive surgical approaches with traditional bypass.
Main Methods:
- Literature review of current minimally invasive strategies.
- Analysis of endovascular techniques (stenting, endografts) and laparoscopic/MIAS approaches.
- Comparison of outcomes and feasibility.
Main Results:
- Endovascular therapies have transformed treatment, enabling reconstruction of complex lesions.
- Laparoscopic surgery and MIAS have faced challenges, limiting widespread adoption.
- These techniques are confined to specialized centers with limited comparative data.
Conclusions:
- Endovascular therapies provide a less invasive option with mortality/morbidity benefits for high-risk patients.
- ABF remains the optimal choice for select, fit patients.
- Further evidence is needed to establish the general applicability of laparoscopic surgery and MIAS compared to endovascular options.
Background:
Peripheral arterial disease (PAD) is a complex and highly prevalent pathology. It has been estimated that ∼8.5 million people in the United States are affected by PAD, of which 12%-20% are older than age 60. The TransAtlantic Inter-Society Consensus (TASC) guidelines classified aortoiliac atherosclerotic disease based on morphology and level of lesions. TASC II guidelines recommend bilateral surgical bypass to the femoral arteries for TASC II C and D lesions. The aortobifemoral bypass (ABF) has been considered the gold standard in the treatment of aortoiliac occlusive disease (AIOD). The long-term patency rate of 85%-90% at 5 years and 75%-80% at 10 years has been for a long time unmatched by other methods of revascularization.
Methods:
This is a review of the current literature regarding minimally invasive strategies in the care of TASC II C and D aortoiliac disease.
Results:
Endovascular therapies have led to a paradigm change even in the treatment of highly advanced lesions. Reconstruction of the aortic bifurcation for distal aortic and/or ostial unilateral/bilateral common iliac artery disease can be achieved via the deployment of stents with "kissing" technique and aortic endografts. Laparoscopic aortoiliac surgery for TASC II C and D lesions was first proposed in 1993. Total laparoscopic, laparoscopic-assisted, and laparobotic techniques have been described. Minimal incision aortic surgery (MIAS) describes abdominal incisions varying from 6 to 12 cm and positional adjustment of retractors to access the retroperitoneum for infrarenal aortic aneurysms and/or AIOD.
Conclusions:
Although initial enthusiasm laparoscopic aortic surgery and MIAS have failed to gain acceptance in the vascular surgery community due to intrinsic procedural challenges, they are currently practiced in few highly specialized centers. At this moment, high-quality evidence is lacking regarding the further feasibility of these techniques and their applicability in general practice compared to endovascular therapies. While the ABF remains still the optimal choice in select, fit for surgery patients, endovascular therapies offer a less invasive approach that may provide a mortality and morbidity benefit in higher risk patients with acceptable short- and long-term outcomes.
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