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Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization

Sydney Webb Strickland1, Nicole Brimer1, Charles Lyons1

  • 1Department of Pathology, University of Virginia, Charlottesville, VA 22901, United States.

Virology
|January 19, 2018
PubMed
Summary

Human papillomavirus (HPV) oncoproteins, specifically E6, bind to cellular PDZ proteins, promoting the nuclear localization of YAP1. This interaction is a key mechanism by which E6 may contribute to cellular transformation.

Keywords:
Adherens junctionsHippoPolarityTAZTight junctions

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