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Joel Blanchard1,2, Samuel Blais1, Philippe Chetaille3

  • 1Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, and Sherbrooke University Hospital Research Center, Sherbrooke, CANADA.

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Summary
This summary is machine-generated.

This study provides Z score equations for pediatric cardiorespiratory fitness (CRF) parameters, offering updated reference values independent of sex and body size. These new equations aim to improve the assessment of CRF in healthy children.

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Area of Science:

  • Pediatric Exercise Physiology
  • Cardiorespiratory Fitness Assessment
  • Biostatistics

Background:

  • Cardiopulmonary exercise testing (CPET) is crucial for evaluating cardiorespiratory fitness (CRF) in children.
  • Existing pediatric reference values for CRF lack independence from body size and pubertal development.
  • A need exists for robust, size-independent pediatric CRF reference data.

Purpose of the Study:

  • To develop Z score equations for maximal and submaximal CRF parameters in children.
  • To establish updated reference values for pediatric CRF using a prospectively recruited healthy cohort.
  • To create prediction curves adjusted for age, sex, and body size.

Main Methods:

  • A cross-sectional, multicenter study involving 228 healthy children aged 12-17 years.
  • Symptom-limited CPET using a progressive ramp protocol on an electronically braked cycle ergometer.
  • Multivariable regression models were employed to normalize 18 CRF parameters, accounting for heteroscedasticity.

Main Results:

  • Nonlinear associations between CRF parameters and body size were identified, along with significant heteroscedasticity.
  • Multivariable models incorporating height, corrected body mass, and age were necessary for normalization.
  • Final prediction models generated adjusted CRF parameters independent of age, sex, body mass, height, BMI, and Tanner stages.

Conclusions:

  • Z score equations for pediatric CRF parameters have been developed from a healthy cohort.
  • These updated reference values provide sex- and size-independent predicted means and normal ranges.
  • Further research is required to evaluate the utility of these values in identifying cardiorespiratory abnormalities in children with chronic conditions.