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Flow Cytometry Purification of Mouse Meiotic Cells
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Spark-generated microbubble cell sorter for microfluidic flow cytometry.

Jingjing Zhao1,2,3, Zheng You1,2,3

  • 1State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing 100084, People's Republic of China.

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
|January 19, 2018
PubMed
Summary
This summary is machine-generated.

A novel microfluidic cell sorter uses spark-generated cavitation microbubbles for high-speed, accurate sorting. This simple, enclosed system enhances biosafety and cell viability for research and clinical applications.

Keywords:
cavitation bubblecell sorterflow cytometermicrofluidicspark-generated bubble

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Cell Biology

Background:

  • High-speed and accurate cell sorting is crucial for bioresearch and clinical diagnostics.
  • Conventional flow cytometers generate aerosols, posing biosafety risks and potentially affecting test accuracy.
  • Existing microfluidic sorters often involve complex designs or suffer from low throughput.

Purpose of the Study:

  • To introduce a novel microfluidic cell sorting mechanism utilizing spark-generated cavitation microbubbles.
  • To develop an easily controllable and simple microfluidic sorter with high throughput and fast switching capabilities.
  • To optimize the sorting mechanism for improved performance and cell viability.

Main Methods:

  • A microfluidic chip was designed incorporating three-dimensional (3D) hydrodynamic focusing and a binary optical element (BOE).
  • A spark-generated cavitation microbubble was employed to induce jet flow for cell sorting.
  • The device was optimized through systematic study of various sorting mechanism aspects.

Main Results:

  • The developed sorter achieved a rapid switching time of 250 μs at a sample flow velocity of 5 m/s.
  • Continuous operation was demonstrated at a frequency of 200 Hz.
  • Cell viability and fluorescence signal stability were maintained during the sorting process.

Conclusions:

  • A new on-chip cell sorting mechanism based on spark-generated cavitation microbubbles was successfully explored.
  • The proposed mechanism offers a simple structure, straightforward control, and fast switching capabilities.
  • This technology holds promise for advancing cell analysis in both research and clinical settings with enhanced biosafety.