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Evoking prescribed spike times in stochastic neurons
Jens Doose1, Benjamin Lindner1
1Bernstein Center for Computational Neuroscience, Berlin 10115, Germany and Physics Department of the Humboldt University Berlin, Berlin 12489, Germany.
Abstract:
Single cell stimulation in vivo is a powerful tool to investigate the properties of single neurons and their functionality in neural networks. We present a method to determine a cell-specific stimulus that reliably evokes a prescribed spike train with high temporal precision of action potentials. We test the performance of this stimulus in simulations for two different stochastic neuron models. For a broad range of parameters and a neuron firing with intermediate firing rates (20-40 Hz) the reliability in evoking the prescribed spike train is close to its theoretical maximum that is mainly determined by the level of intrinsic noise.
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