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Updated: Feb 15, 2026

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
Published on: January 19, 2019
Neuronal network model of interictal and recurrent ictal activity
M A Lopes1,2,3,4, K-E Lee4,5, A V Goltsev4,6
1Living Systems Institute, University of Exeter, Exeter EX4 4QD, United Kingdom.
Abstract:
We propose a neuronal network model which undergoes a saddle node on an invariant circle bifurcation as the mechanism of the transition from the interictal to the ictal (seizure) state. In the vicinity of this transition, the model captures important dynamical features of both interictal and ictal states. We study the nature of interictal spikes and early warnings of the transition predicted by this model. We further demonstrate that recurrent seizures emerge due to the interaction between two networks.
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