Related Experiment Video
Updated: Feb 15, 2026

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
Published on: August 11, 2017
Pharmaceutical equivalent dissertation of Metformin hydrochloride brands
Safila Naveed1, Huma Dilshad1, Maheen Nafees1
1Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan.
Abstract:
The aim of study is to establish pharmaceutical equivalence of different brands of Metformin tablets available in Karachi, Pakistan. The quality control parameters which are studied are weight variation test, hardness test, thickness, friability, disintegration and dissolution specified by BP/USP (British and United State Pharmacopoeia). Weight variation and hardness value requirement was complied by all brands. Disintegration time for all brands was within range i.e. 15 minutes and also complies with the BP/USP recommendation. All brands showed more than 90% drug release within forty five minutes. The present conclusion suggests that almost all the brands of Metformin that are available in Karachi meet the specification for quality control analysis. Assay performed by HPLC by keeping flow rate of 1.0 ml/min of the mobile phase and the quantitative evaluation at 225 nm was performed. The retention time of Metformin was found to be 2.5min. Method suitability for the quantitative determination of the drugs was proved by validation according to the International Conference on Harmonization (ICH) guidelines.
Related Concept Videos
Pharmaceutical Equivalents
Equivalent Capacitance
The following strategies are adopted to calculate...
Equivalent Capacitance
Thévenin Equivalent Circuits
Principle of Equivalence
Equivalent Couples
Two couples are considered to be equivalent if they produce the same rotational effect on a rigid body. In other words, the two couples have the same magnitude and act in the same direction, causing the same angular displacement or acceleration in the body.
For instance, consider two couples lying in the plane of the page, with one having a pair of equal...

