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The INs and OUTs of mitofusins
Marta Giacomello1, Luca Scorrano2,3
1Department of Biology, University of Padua, Padua, Italy.
Abstract:
Mitofusins are outer membrane proteins essential for mitochondrial fusion. Their accepted topology posits that both N and C termini face the cytoplasm. In this issue, Mattie et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201611194) demonstrate instead that their C termini reside in the intermembrane space. These findings call for a revision of the current models of mitochondrial fusion.
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