Related Experiment Video
Updated: Jul 29, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
'Clinically suspected myocarditis with pseudoinfarct presentation' complicated with left ventricular aneurysm
1Heart and Vascular Institute, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.
Insights
Acute myocarditis can rarely cause transmural myocardial necrosis and aneurysm, mimicking a heart attack. This case highlights an unusual complication of myocarditis, emphasizing careful monitoring for pseudoinfarct presentations.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Pathology
Background:
- Myocarditis is an inflammatory condition of the heart muscle.
- Pseudoinfarct presentation of myocarditis can mimic acute myocardial infarction.
- Transthoracic echocardiography (TTE) and Cardiac Magnetic Resonance (CMR) are key diagnostic tools.
Observation:
- A 51-year-old man presented with symptoms suggestive of myocardial infarction but had a normal coronary angiogram.
- Cardiac MR revealed findings typical of myocarditis, including edema and late gadolinium enhancement.
- An apical transmural scar with aneurysm developed rapidly within two weeks, an atypical evolution for myocarditis.
Findings:
- The patient developed an apical transmural myocardial necrosis with aneurysm, an unusual complication of acute myocarditis.
- Persistent Q waves and apical aneurysm were noted on TTE seven years later.
- This case underscores the potential for severe, infarct-like complications in myocarditis.
Implications:
- Myocarditis should be considered in patients with pseudoinfarct presentations, even with normal coronary arteries.
- Close monitoring is crucial for patients diagnosed with myocarditis due to the risk of atypical complications.
- Understanding these rare complications can improve diagnostic accuracy and patient management strategies.
Abstract:
A 51-year-old man presented with chest pain, high troponin level, inflammatory syndrome and ST-segment elevation in the anterior leads. While the transthoracic echocardiogram (TTE) showed anteroseptal hypokinesis and apical akinesis, the coronary angiogram was normal. Cardiac MR demonstrated a typical aspect of myocarditis (multiple areas of mid-myocardial late gadolinium enhancement, sparing the subendocardial layer, along with oedema). The initial diagnosis was clinically suspected myocarditis with pseudoinfarct presentation. However, the short-term evolution was not typical of this syndrome, since an apical transmural scar with aneurysm developed within 2 weeks. Seven years later, the patient remained asymptomatic, while Q waves persisted in anterior leads along with an apical aneurysm on TTE. A transmural myocardial necrosis with aneurysm is an unusual complication of acute myocarditis. The potential mechanisms accounting for the development of these lesions are reviewed, and the clinical implications for the diagnosis and monitoring of acute myocarditis are discussed.
Related Concept Videos
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Myocarditis I: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis III: Medical Management

