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Tracking brain damage in progressive supranuclear palsy: a longitudinal MRI study.

Federica Agosta1, Francesca Caso1,2, Milica Ječmenica-Lukić3

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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|January 20, 2018
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Summary

Progressive supranuclear palsy-Richardson's syndrome (PSP-RS) shows significant midbrain atrophy and white matter (WM) damage progression over time. These changes correlate with disease severity and behavioral dysfunction, highlighting MRI's role in tracking PSP-RS.

Keywords:
cortical thicknessdiffusion tensor MRImagnetic resonance imaging (MRI)midbrain volumeprogressive supranuclear palsyrichardson syndromewhite matter

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Area of Science:

  • Neuroimaging
  • Neurology
  • Pathology

Background:

  • Progressive supranuclear palsy-Richardson's syndrome (PSP-RS) is a neurodegenerative disorder.
  • Understanding PSP-RS brain changes is crucial for diagnosis and management.

Purpose of the Study:

  • Investigate clinical and brain structural changes in PSP-RS using multiparametric MRI.
  • Assess longitudinal changes in grey matter and white matter (WM) in PSP-RS patients.

Main Methods:

  • Prospective, longitudinal study of 21 PSP-RS patients and 36 healthy controls.
  • Utilized multiparametric MRI, clinical rating scales, and neuropsychological tests.
  • Evaluations conducted at baseline and after a mean 1.4-year follow-up.

Main Results:

  • PSP-RS patients exhibited baseline midbrain atrophy, frontal cortical thinning, and widespread WM damage.
  • Longitudinal analysis revealed significant progression in midbrain atrophy and WM damage.
  • Corpus callosum and frontal WM changes correlated with increased disease severity and behavioral dysfunction.

Conclusions:

  • Longitudinal diffusion tensor MRI is feasible and sensitive for tracking PSP-RS pathology progression.
  • Midbrain volume loss and WM changes are key indicators of PSP disease course.