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Ginseng and obesity.

Zhipeng Li1, Geun Eog Ji1,2

  • 1Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, Republic of Korea.

Journal of Ginseng Research
|January 20, 2018
PubMed
Summary
This summary is machine-generated.

Ginseng may aid weight management by increasing energy expenditure and reducing food intake. However, more human studies are needed to confirm its effectiveness in humans for obesity treatment.

Keywords:
AMPKginsengginsenosidelipid metabolismobesity

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Area of Science:

  • Pharmacology
  • Metabolism
  • Obesity Research

Background:

  • Ginseng exhibits potential antiobesity effects, but the underlying mechanisms are not fully understood.
  • Obesity is a complex metabolic disorder with significant health implications.
  • Ginseng's impact on metabolic pathways warrants further investigation.

Purpose of the Study:

  • To elucidate the mechanisms by which ginseng exerts its antiobesity effects.
  • To evaluate ginseng's influence on food intake, digestion, and absorption.
  • To examine ginseng's effects on key metabolic tissues like the liver, adipose tissue, and skeletal muscle.

Main Methods:

  • Review of existing in vitro and in vivo studies on ginseng and its active compounds (ginsenosides).
  • Analysis of ginseng's impact on energy expenditure via the adenosine monophosphate-activated kinase (AMPK) pathway.
  • Investigation of ginseng's role in regulating energy intake and adipogenesis.

Main Results:

  • Ginseng and ginsenosides can enhance energy expenditure by activating the AMPK pathway.
  • Ginseng demonstrates a capacity to reduce overall energy intake.
  • Ginseng exhibits a dual regulatory effect on adipogenesis in high-fat diet-induced obese and diabetic models.

Conclusions:

  • Ginseng possesses multifaceted mechanisms for potential antiobesity effects, including increased energy expenditure and reduced intake.
  • Ginseng influences key metabolic processes and tissues involved in obesity.
  • Further clinical trials in humans are essential to validate ginseng's efficacy for weight management.