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Related Experiment Video

Updated: Feb 15, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Gintonin absorption in intestinal model systems.

Byung-Hwan Lee¹, Sun-Hye Choi¹, Hyeon-Joong Kim¹

¹Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.

Journal of Ginseng Research

|January 20, 2018

Summary

Gintonin, a novel compound from ginseng, is absorbed in the intestine via passive diffusion, paracellular, and active transport. Its lipid component is crucial for this intestinal absorption process.

Keywords:

Panax ginseng everted intestinal sac gintonin gintonin absorption

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Last Updated: Feb 15, 2026

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Area of Science:

Pharmacology
Gastroenterology
Biochemistry

Background:

Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, has demonstrated anti-Alzheimer effects.
Its role in cellular processes like morphology, proliferation, and migration is established.
However, the intestinal absorption of gintonin remains largely uncharacterized.

Purpose of the Study:

To investigate the intestinal absorption mechanisms of gintonin.
To evaluate the influence of various factors on gintonin absorption in vitro.

Main Methods:

Parallel artificial membrane permeation assay (PAMPPA) to assess membrane permeability.
Mouse everted intestinal sac model to evaluate in vivo absorption.
Inhibition studies using Rho kinase and sodium-glucose transporter inhibitors.

Main Results:

Gintonin demonstrated dose-dependent permeation across an artificial membrane.
Absorption in the everted sac model showed time- and dose-dependency, with saturation observed.
Inhibition by Y-27632 and phloridzin, and attenuation by lipid extraction, suggested involvement of active transport and the lipid component.

Conclusions:

Gintonin is absorbed in the intestine through a combination of transcellular diffusion, paracellular diffusion, and active transport.
The lipid component of gintonin appears to play a significant role in its intestinal absorption.