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Spontaneous Infraslow Fluctuations Modulate Hippocampal EPSP-PS Coupling.

Michael B Dash1,2, Stephen Ajayi2, Lynde Folsom2

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Eneuro
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Summary

Spontaneous brain activity (SBA) influences hippocampal responses. Infraslow SBA fluctuations modulate neuronal excitability, affecting sensory selection and information processing by altering how the brain responds to identical inputs.

Keywords:
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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Trial-to-trial variability is common in brain function.
  • Spontaneous brain activity (SBA) may underlie this variability by altering neuronal excitability.
  • Hippocampal function is crucial for memory and cognition.

Purpose of the Study:

  • To investigate the relationship between spontaneous brain activity and hippocampal evoked responses in freely-behaving rats.
  • To determine if SBA fluctuations are coordinated and influence neuronal output heterogeneity.
  • To understand the role of infraslow SBA in modulating information processing.

Main Methods:

  • Recording hippocampal evoked responses in male rats under constant medial perforant path stimulation.
  • Analyzing spontaneous brain activity (SBA) in the 4-second window preceding stimulation.
  • Quantifying band-limited power (BLP) in low (0.5-9 Hz) and high (40.25-100 Hz) frequencies.
  • Examining infraslow (0.005-0.02 Hz) fluctuations in SBA and their correlation with evoked response parameters (fEPSP slope, population spike amplitude).

Main Results:

  • Extensive variability in hippocampal evoked responses was observed despite constant stimulation.
  • Increased low- and high-frequency SBA power preceded decreased fEPSP slope and increased population spike (PS) amplitude.
  • Infraslow SBA fluctuations were coordinated and exhibited distinct phase relationships with fEPSP slope and PS amplitude changes.
  • SBA dynamically modulated EPSP-PS coupling, leading to heterogeneous hippocampal outputs from identical inputs.

Conclusions:

  • Infraslow spontaneous brain activity plays a critical role in shaping hippocampal output variability.
  • SBA dynamically alters neuronal excitability and EPSP-PS coupling, influencing information processing and sensory selection.
  • Endogenous neuronal activity, particularly infraslow SBA, is fundamental for modulating the brain's response to stimuli.