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Melanuria.

P T Valente, B F Atkinson, D Guerry

    Acta Cytologica
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Metastatic malignant melanoma can cause diffuse melanosis and melanuria. Urinary cytology revealed dark-brown casts and pigment-laden macrophages, indicating melanin deposition.

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    Area of Science:

    • Oncology
    • Pathology
    • Dermatology

    Background:

    • Metastatic malignant melanoma is an advanced form of skin cancer.
    • Diffuse melanosis presents as slate-blue skin discoloration due to melanin deposition.
    • Melanuria is the presence of melanin pigment in the urine.

    Observation:

    • Urinary cytology was performed on a patient with metastatic malignant melanoma.
    • Clinical examination revealed generalized slate-blue skin discoloration (melanosis).
    • Microscopic analysis of urine showed characteristic findings.

    Findings:

    • The melanosis was attributed to dermal deposition of excess melanin pigment.
    • Microscopically, melanuria was characterized by amorphous, dark-brown casts.
    • These casts stained positively for melanin pigment.
  • Numerous pigment-laden macrophages were also observed in the urine.

    • Implications:

    • Urinary cytology can aid in diagnosing melanuria associated with metastatic melanoma.
    • These findings highlight the systemic deposition of melanin in advanced melanoma.
    • Understanding these cytologic features is crucial for accurate diagnosis and patient management.