Related Experiment Video

Updated: Feb 15, 2026

Survivable Stereotaxic Surgery in Rodents
00:08

Survivable Stereotaxic Surgery in Rodents

Published on: October 6, 2008

70.2K

Does the interval from tumour surgery to radiotherapy influence survival in paediatric high grade glioma?

Amedeo A Azizi1, Simon Paur2, Alexandra Kaider3

  • 1Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria. amedeo.azizi@meduniwien.ac.at.

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]
|January 20, 2018
PubMed

Insights

The interval between surgery and radiotherapy did not impact survival for pediatric high-grade glioma (pHGG) patients. This finding supports molecular testing before treatment initiation in pHGG cases.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Radiation Oncology

Background:

  • Pediatric high-grade glioma (pHGG) is rare, with radiotherapy being a standard treatment post-surgery.
  • The impact of the interval from surgery to radiotherapy (ISRT) on survival in pediatric patients is not well-established.
  • Existing data primarily focuses on adult glioblastoma, leaving a gap in pediatric knowledge.

Purpose of the Study:

  • To investigate the potential influence of the interval from surgery to radiotherapy (ISRT) on survival outcomes in pediatric high-grade glioma (pHGG) patients.
  • To analyze survival data in relation to ISRT in a cohort of children and adolescents diagnosed with non-pontine HGG.
  • To provide evidence-based insights for optimizing treatment protocols in pediatric HGG management.

Main Methods:

  • Retrospective single-center analysis of pediatric patients (3-19 years) with non-pontine HGG.
  • Inclusion of 38 patients with varying grades (3 and 4) and extents of resection (gross total, partial, biopsy only).
  • Analysis of overall survival (OS) and progression-free survival (PFS) in relation to ISRT, tumor grade, extent of resection, and chemotherapy regimens.

Main Results:

  • ISRT, whether analyzed continuously or dichotomized, did not significantly affect OS or PFS in pediatric HGG patients.
  • Higher extent of resection, lower tumor grade, and temozolomide chemotherapy showed a significant positive impact on OS and PFS.
  • Patients with grade 4 tumors were more likely to receive radiotherapy sooner after surgery.

Conclusions:

  • The interval from surgery to radiotherapy (ISRT) does not appear to influence survival in pediatric high-grade glioma (pHGG).
  • The findings suggest that it is safe to conduct molecular analyses within a four-week period before initiating radiotherapy for pHGG.
  • This supports the integration of molecular profiling into treatment planning for upcoming targeted therapies in pediatric HGG.
Abstract

Keywords:
ChildrenHGGHigh grade gliomaPaediatric oncologyRadiotherapy

More Related Videos

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas06:27

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

1.2K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

936

Related Concept Videos

Prediction Intervals01:03

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.4K
Graded Potential01:19

Graded Potential

Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.2K
Confidence Intervals01:21

Confidence Intervals

An unbiased point estimate is often insufficient to predict a population estimate, such as population mean or population proportion. In this scenario, a confidence interval is used. A confidence interval is an estimate similar to a  sample proportion. However, unlike the point estimate which is a single value, the confidence interval  contains a range of values. These values have lower and upper limits, known as confidence limits, and can be designated as L1 and L2, respectively.
A...
10.8K
Survival Curves01:18

Survival Curves

Survival curves are graphical representations that depict the survival experience of a population over time, offering an intuitive way to track the proportion of individuals who remain event-free at each time point. These curves are widely used in fields such as medicine, public health, and reliability engineering to visualize and compare survival probabilities across different groups or conditions.
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
751
Survival Tree01:19

Survival Tree

Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
 Building a Survival Tree
Constructing a...
439
Improper Integrals: Infinite Intervals01:29

Improper Integrals: Infinite Intervals

An integral is classified as improper due to an infinite interval when at least one of its limits of integration extends to positive or negative infinity. In such cases, the region under the curve is unbounded, and standard techniques for evaluating definite integrals are not directly applicable. Instead, the improper integral is defined through a limiting process that allows one to determine whether the accumulated area remains finite despite the infinite domain.Application to Exponential...
118