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Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
Published on: June 18, 2020
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Membranous glomerulonephritis with an LMNA mutation.
1Department of Diagnostic Pathology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, Japan. fujiko@tenriyorozu.jp.
CEN Case Reports
|January 20, 2018
Summary
A rare case links membranous glomerulonephritis (MGN) and dilated cardiomyopathy caused by an LMNA gene mutation. This finding suggests LMNA gene mutations may underlie some cases of unexplained MGN.
Area of Science:
- Cardiology
- Nephrology
- Genetics
Background:
- Membranous glomerulonephritis (MGN) is a leading cause of nephrotic syndrome in adults.
- Dilated cardiomyopathy is a significant cause of heart failure.
- LMNA gene mutations are associated with various 'laminopathies', including cardiomyopathies and muscular dystrophies.
Purpose of the Study:
- To report a unique case of concurrent membranous glomerulonephritis and dilated cardiomyopathy.
- To investigate the potential genetic link between LMNA gene mutations and these conditions.
Main Methods:
- Case report detailing clinical presentation, diagnostic workup, and genetic testing.
- Review of literature on LMNA gene mutations and associated phenotypes.
Main Results:
- The patient presented with clinical and histological findings of membranous glomerulonephritis.
- Cardiomyopathy was diagnosed, and genetic analysis revealed a mutation in the LMNA gene.
- LMNA gene mutations are established causes of dilated cardiomyopathy and other neuromuscular disorders.
Conclusions:
- This case highlights a potential association between LMNA gene mutations and membranous glomerulonephritis.
- The LMNA gene may be a genetic factor contributing to cryptogenic (idiopathic) membranous glomerulonephritis.
- Further research is warranted to explore the role of LMNA gene mutations in the pathogenesis of MGN.
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