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Related Experiment Video

Updated: Jun 24, 2026

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres

Published on: November 8, 2014

Is DCIS Overrated?

Joshua Feinberg¹, Rachel Wetstone², Dana Greenstein²

¹Department of Surgery, Maimonides Breast Center, Maimonides Medical Center, Research Fellow, Oxford University, Oxford, England.

Cancer Treatment and Research

|January 20, 2018

Summary

Ductal carcinoma in situ (DCIS) is often overdiagnosed and overtreated, as most cases are indolent and unlikely to progress. New genomic tools show promise in identifying which DCIS patients truly need treatment.

Keywords:

Breast cancer Breast cancer genomic profiling Breast cancer screening DCIS Ductal carcinoma in situ

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Last Updated: Jun 24, 2026

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres

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Published on: November 8, 2014

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Published on: May 20, 2015

Real-Time Detection and Capture of Invasive Cell Subpopulations from Co-Cultures

Real-Time Detection and Capture of Invasive Cell Subpopulations from Co-Cultures

Published on: March 30, 2022

Area of Science:

Oncology
Genomics
Breast Cancer Research

Background:

Ductal carcinoma in situ (DCIS) is the noninvasive form of breast cancer, accounting for over 20% of US diagnoses.
Current treatments include local excision with radiation or mastectomy, with endocrine therapy for ER-positive cases.
Despite high survival rates, the necessity of aggressive treatment for all DCIS is questioned due to its indolent nature in many cases.

Purpose of the Study:

To evaluate the overdiagnosis and overtreatment of DCIS.
To explore the indolent nature of a significant subset of DCIS.
To assess the potential of new genomic tools in predicting DCIS progression.

Main Methods:

Review of existing evidence on DCIS incidence, treatment, and outcomes.
Analysis of autopsy series, missed-diagnosis studies, and retrospective reviews.
Introduction of a novel 12-gene expression profiling tool (Oncotype DCIS) for risk stratification.

Main Results:

DCIS incidence correlates with screening mammography utilization, suggesting overdiagnosis.
Evidence indicates that the majority of DCIS cases are indolent and may not progress to invasive cancer.
The 12-gene assay demonstrates promise in predicting the biological behavior of DCIS.

Conclusions:

Patient and physician misconceptions contribute to the overdiagnosis and overtreatment of DCIS.
A significant proportion of DCIS may be indolent, questioning the need for aggressive intervention.
Genomic profiling offers a potential solution for personalized DCIS management, avoiding unnecessary treatments.