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Implantation of Total Artificial Heart in Congenital Heart Disease
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Hybrid Continuous-Flow Total Artificial Heart.

Carson Fox1, Steven Chopski1, Nohra Murad1

  • 1The BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.

Artificial Organs
|January 20, 2018
PubMed
Summary

A new hybrid total artificial heart (TAH) design offers improved quality of life for heart failure patients. This magnetically-levitated device aims to overcome limitations of current TAHs, enhancing patient mobility and reducing risks.

Keywords:
-Pediatric circulatory support-Rotary blood pump-Total artificial heart-Ventricular assist device-blood pumpMechanical circulatory assistance

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Science
  • Medical Devices

Background:

  • Total artificial hearts (TAHs) improve quality of life for pediatric and adult heart failure patients.
  • Existing TAHs face limitations such as thromboembolic events, infection risk, and restricted ambulation.
  • There is a need for advanced TAH designs addressing these clinical challenges.

Purpose of the Study:

  • To develop a novel hybrid-design, magnetically-levitated TAH for pediatric and adult heart failure.
  • To overcome design limitations of current TAHs, including size, infection risk, and patient mobility.
  • To create a more compact, nonthrombogenic, and effective therapeutic alternative.

Main Methods:

  • Developed a hybrid-design, continuous-flow, magnetically-levitated TAH with two moving parts (axial and centrifugal impellers).
  • Utilized magnetic bearing technology and established initial geometries using pump design equations.
  • Employed computational modeling for performance insights, followed by prototype manufacturing and hydraulic testing.

Main Results:

  • The TAH prototype successfully delivered target blood flow rates of 1-6.5 L/min.
  • Achieved pressure rises of 1-92 mm Hg (pulmonary) and 24-150 mm Hg (systemic) at 1500-10,000 rpm.
  • Initial design demonstrated capability to meet critical hemodynamic parameters.

Conclusions:

  • The developed TAH design is a promising foundation for a novel therapeutic alternative.
  • This device has the potential to be more compact, nonthrombogenic, and effective for heart failure patients.
  • Further development aims to provide improved ambulation and reduced complication risks for infants, children, adolescents, and adults.