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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
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New and developing pharmacotherapy for osteoporosis in men
Luigi Gennari1, John P Bilezikian2
1a Department Medicine, Surgery and Neurosciences , University of Siena , Siena , Italy.
Expert Opinion on Pharmacotherapy
|January 20, 2018
Summary
Osteoporosis treatment in men is less defined than in women. Bisphosphonates are first-line, while newer drugs may offer more targeted bone formation or resorption inhibition for better osteoporosis management.
Area of Science:
- Endocrinology
- Bone Biology
- Pharmacology
Background:
- Osteoporosis is a significant health burden affecting both men and women.
- Men are underdiagnosed and undertreated for osteoporosis and fracture prevention, even post-fracture.
Purpose of the Study:
- To summarize current drug therapies for male osteoporosis.
- To provide insights into emerging pharmacotherapies for osteoporosis in men.
Main Methods:
- Review of available scientific literature and clinical evidence.
- Analysis of current therapeutic guidelines and emerging drug development.
Main Results:
- Therapeutic strategies for male osteoporosis are less established than for women due to limited antifracture efficacy data.
- Bisphosphonates are the current first-line pharmacotherapy for men.
- Osteoanabolic agents like teriparatide may suit men with primary osteoporosis and low bone turnover, but have limitations.
Conclusions:
- Future osteoporosis pharmacotherapy for men may involve selective antiresorptive agents and novel osteoanabolic drugs.
- Advances in bone biology are paving the way for more targeted and effective treatments for male osteoporosis.
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