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A new polyoxygenated abietane diterpenoid from the rattans of Bauhinia championii (Benth.) Benth
Li-Ping Hua1, Yu-Qin Zhang1, Miao Ye1
1a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.
Abstract:
A new polyoxygenated abietane diterpenoid, bauchampine A (1), together with seven known compounds (2-8), were isolated from the rattans of Bauhinia championii (Benth.) Benth. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with the data reported in the literature. New compound 1 was evaluated for its anti-rheumatoid arthritis activity via examining its anti-proliferative effect on synoviocytes in vitro. Compound 1 exhibited inhibitory effect on the proliferation of synoviocytes with IC50 value comparable to that of methotrexate.
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