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Updated: Feb 15, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications
Jörn Lötsch1,2, Dario Kringel1
1Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany.
Abstract:
The novel research area of functional genomics investigates biochemical, cellular, or physiological properties of gene products with the goal of understanding the relationship between the genome and the phenotype. These developments have made analgesic drug research a data-rich discipline mastered only by making use of parallel developments in computer science, including the establishment of knowledge bases, mining methods for big data, machine-learning, and artificial intelligence, (Table ) which will be exemplarily introduced in the following.
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