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Critical effects of long non-coding RNA on fibrosis diseases

Yue Zhang1,2,3, Gang Luo2, Yi Zhang4

  • 1Department of Dermatology, 105th Hospital of PLA, Hefei, China.

Experimental & Molecular Medicine
|January 20, 2018
PubMed

Insights

Long non-coding RNAs (lncRNAs) are implicated in various diseases and regulate fibrosis. This review covers lncRNAs in liver, heart, kidney, lung, and peritoneal fibrosis, highlighting their therapeutic potential.

Area of Science:

  • Molecular Biology
  • Genetics
  • Pathology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in diverse diseases, including hereditary, autoimmune, metabolic, and oncological conditions.
  • Fibrosis, a pathological process common in many diseases and a primary feature of fibrotic disorders, is now understood to be regulated by lncRNAs.

Purpose of the Study:

  • To review the latest research on the role of lncRNAs in fibrotic diseases affecting major organs.
  • To explore the potential of lncRNAs as therapeutic targets for human fibrotic diseases.

Main Methods:

  • Literature review of recent findings on lncRNAs in fibrosis.
  • Analysis of lncRNA involvement in liver, myocardial, kidney, lung, and peritoneal fibrosis.

Main Results:

  • lncRNAs are significant regulators in the pathogenesis of fibrosis across multiple organs.
  • Dysregulation of specific lncRNAs is associated with the development and progression of fibrotic diseases.

Conclusions:

  • lncRNAs play a crucial role in the development of fibrosis in the liver, heart, kidney, lung, and peritoneum.
  • Targeting disease-related lncRNAs offers promising therapeutic strategies for treating human fibrotic diseases.

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