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[Thyroid dysfunction induced by amiodarone].

C Posadas, R Olguín, E Baltazares

    Archivos Del Instituto De Cardiologia De Mexico
    |September 1, 1985
    PubMed
    Summary
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    Amiodarone, a cardiac arrhythmia drug, can cause thyroid dysfunction due to its iodine content. This study observed 18 patients developing various thyroid issues, including thyrotoxicosis and hypothyroidism, during amiodarone treatment.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Pharmacology

    Context:

    • Amiodarone is a widely prescribed antiarrhythmic medication.
    • Its chemical structure, high iodine content, and thyroxine similarity can impact thyroid function.
    • Pre-existing thyroid conditions may influence susceptibility.

    Purpose:

    • To investigate the spectrum and incidence of thyroid dysfunction in patients treated with amiodarone.
    • To analyze the relationship between amiodarone dosage/duration and thyroid abnormalities.
    • To describe the clinical presentation and outcome of amiodarone-induced thyroid disease.

    Summary:

    • Eighteen patients (11 female, 7 male) developed thyroid disease during amiodarone therapy.
    • Thyroid dysfunction manifested as thyrotoxicosis (9 patients), diffuse thyroid enlargement (3 patients), or hypothyroidism (6 patients).

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  • Onset ranged from 1 to 29 months; no dose-response relationship was found. Symptoms generally resolved after amiodarone withdrawal.

    • Impact:

    • Confirms amiodarone's potential to induce diverse thyroid abnormalities.
    • Highlights the importance of monitoring thyroid function in patients on amiodarone.
    • Provides clinical insights into managing amiodarone-associated thyroid dysfunction.