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Associations between microalbuminuria and parameters of flow-mediated vasodilatation obtained by continuous

Rie Koyoshi1, Yuka Hitaka-Yoshimine2, Yuhei Shiga2

  • 1a Division of Medical Safety Management , Fukuoka University Hospital , Fukuoka , Japan.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|January 20, 2018
PubMed

Insights

Microalbuminuria is linked to endothelial dysfunction, with lower integrated flow-mediated dilation (FMD-AUC120) indicating increased risk. This finding may help identify patients with microalbuminuria earlier.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Vascular Biology

Background:

  • Microalbuminuria is a marker of endothelial dysfunction, but its association with specific flow-mediated dilation (FMD) parameters requires further clarification.
  • Endothelial dysfunction contributes to cardiovascular disease progression.

Purpose of the Study:

  • To investigate the relationship between microalbuminuria and various quantitative measures of FMD.
  • To identify potential FMD markers for detecting microalbuminuria.

Main Methods:

  • Retrospective analysis of 265 patients undergoing coronary angiography.
  • Measurement of FMD using 15 approaches, including brachial artery diameter change (bFMD), dilation rate (FMD-MDR), and integrated response (FMD-AUC60, FMD-AUC120).
  • Comparison of FMD parameters between normoalbuminuria and microalbuminuria groups, with multiple regression and ROC analysis.

Main Results:

  • The microalbuminuria group had a higher prevalence of coronary artery disease.
  • Integrated FMD responses (FMD-AUC60, FMD-AUC120) were significantly lower in the microalbuminuria group.
  • FMD-AUC120 and diabetes mellitus were identified as predictors of microalbuminuria, with a defined cut-off value for FMD-AUC120.

Conclusions:

  • This study confirms the association between microalbuminuria and endothelial dysfunction.
  • The integrated FMD response over 120 seconds (FMD-AUC120) shows promise as a superior marker for microalbuminuria detection.
Keywords:
Urinary albumin-creatinine ratioarea under the dilation curvecoronary artery disease

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