Related Experiment Video
Updated: Feb 15, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease
Daniel S Matasic1,2,3, Charles Brenner3,4, Barry London1,2,3
1Division of Cardiovascular Medicine, Department of Medicine, University of Iowa , Iowa City, Iowa.
Abstract:
Nicotinamide adenine dinucleotide (NAD+) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD+ is required for the activity of multifunctional enzymes, including sirtuins and poly(ADP-ribose) polymerases that regulate posttranslational modifications, DNA damage responses, and Ca2+ signaling. Recent research has indicated that NAD+ participates in a multitude of processes dysregulated in cardiovascular diseases. Therefore, supplementation of NAD+ precursors, including nicotinamide riboside that boosts or repletes the NAD+ metabolome, may be cardioprotective. This review examines the molecular physiology and preclinical data with respect to NAD+ precursors in heart failure-related cardiac remodeling, ischemic-reperfusion injury, and arrhythmias. In addition, alternative NAD+-boosting strategies and potential systemic effects of NAD+ supplementation with implications on cardiovascular health and disease are surveyed.
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