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Pneumococcal meningitis trends after pneumococcal conjugate vaccine introduction in Colombia: An interrupted

Diana C Caceres1, Eduardo Ortega-Barria2, Javier Nieto2

  • 1a GSK , Bogotá , Colombia.

Human Vaccines & Immunotherapeutics
|January 20, 2018
PubMed

Insights

Colombia

Area of Science:

  • Public Health
  • Epidemiology
  • Vaccinology

Background:

  • Colombia implemented widespread pneumococcal conjugate vaccination in late 2011.
  • Pneumococcal meningitis remains a significant public health concern globally.

Purpose of the Study:

  • To evaluate the impact of pneumococcal conjugate vaccination on pneumococcal meningitis incidence in Colombia.
  • To assess the specificity of the observed trends by comparing them with control diseases.

Main Methods:

  • Retrospective analysis of surveillance data from 2005 to 2015.
  • Interrupted time-series analysis to identify changes in disease trends post-vaccination.

Main Results:

  • A significant downward trend in monthly pneumococcal meningitis cases was observed post-vaccination (2012-2015).
  • By 2015, a 90.5% reduction in pneumococcal meningitis incidence was achieved.
  • No similar trend was detected for control diseases, indicating specificity.

Conclusions:

  • Mass pneumococcal conjugate vaccination has been highly effective in reducing pneumococcal meningitis in Colombia.
  • The findings support the public health benefits of widespread pneumococcal conjugate vaccination programs.

Keywords:
ColombiaPneumococcal conjugate vaccinemeningitis

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