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Intensive versus conventional blood pressure monitoring in a general practice population. The Blood Pressure
Pia Klarskov1, Lia E Bang2, Peter Schultz-Larsen3
1Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg University Hospitals, Copenhagen, Denmark.
Insights
Intensive blood pressure monitoring showed similar blood pressure reduction to conventional methods. However, the intensive approach improved cardiovascular risk profiles through non-blood pressure-related effects.
Area of Science:
- Cardiology
- Hypertension Management
- Preventive Medicine
Background:
- Essential hypertension is a major risk factor for cardiovascular disease.
- Effective blood pressure monitoring is crucial for managing hypertension and preventing complications.
- Conventional monitoring methods may not always capture the full picture of blood pressure variability.
Purpose of the Study:
- To compare the effectiveness of conventional versus intensive blood pressure monitoring regimens.
- To assess the impact of different monitoring strategies on blood pressure control in hypertensive patients.
- To evaluate changes in cardiovascular risk profiles associated with intensive monitoring.
Main Methods:
- A randomized controlled trial involving 1048 patients with essential hypertension across 110 Danish general practices.
- Participants were assigned to either conventional (usual) blood pressure monitoring or intensive monitoring (frequent home and 24-hour ambulatory monitoring).
- The study involved a 12-month follow-up period to assess outcomes.
Main Results:
- Both conventional and intensive blood pressure monitoring strategies resulted in similar reductions in 24-hour ambulatory blood pressure.
- Cardiovascular risk scores decreased in both groups by the end of the study.
- The intensive monitoring group exhibited a significantly greater reduction in cardiovascular risk scores compared to the conventional group (P = 0.02).
Conclusions:
- Intensive blood pressure monitoring strategies offer comparable blood pressure reduction to conventional methods.
- Intensive monitoring may confer additional cardiovascular benefits beyond blood pressure lowering.
- Further research into the mechanisms behind these additional benefits is warranted.
Objective:
To compare the effect of a conventional to an intensive blood pressure monitoring regimen on blood pressure in hypertensive patients in the general practice setting.
Design:
Randomized controlled parallel group trial with 12-month follow-up.
Setting:
One hundred and ten general practices in all regions of Denmark.
Participants:
One thousand forty-eight patients with essential hypertension.
Intervention:
Conventional blood pressure monitoring ('usual group') continued usual ad hoc blood pressure monitoring by office blood pressure measurements, while intensive blood pressure monitoring ('intensive group') supplemented this with frequent home blood pressure monitoring and 24-hour ambulatory blood pressure monitoring.
Primary Outcome Measures:
Mean day- and night-time systolic and diastolic 24-hour ambulatory blood pressure.
Secondary Outcome Measures:
Change in systolic and diastolic office blood pressure and change in cardiovascular risk profile.
Results:
Of the patients, 515 (49%) were allocated to the usual group, and 533 (51%) to the intensive group. The reductions in day- and night-time 24-hour ambulatory blood pressure were similar (usual group: 4.6 ± 13.5/2.8 ± 82 mmHg; intensive group: 5.6 ± 13.0/3.5 ± 8.2 mmHg; P = 0.27/P = 0.20). Cardiovascular risk scores were reduced in both groups at follow-up, but more so in the intensive than in the usual group (P = 0.02).
Conclusion:
An intensive blood pressure monitoring strategy led to a similar blood pressure reduction to conventional monitoring. However, the intensive strategy appeared to improve patients' cardiovascular risk profile through other effects than a reduction of blood pressure.
Trial Registration:
Clinical Trials NCT00244660.
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