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Myeloperoxidase and Neurological Disorder: A Crosstalk

Kanta Pravalika1, Deepaneeta Sarmah1, Harpreet Kaur1

  • 1Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad Gandhinagar , 382 355 Gujarat , India.

ACS Chemical Neuroscience
|January 21, 2018
PubMed

Insights

Myeloperoxidase (MPO) is an inflammatory enzyme that contributes to oxidative stress and neurological disorders. Targeting MPO offers potential as a diagnostic biomarker and therapeutic strategy for these conditions.

Area of Science:

  • Biochemistry
  • Immunology
  • Neuroscience

Background:

  • Myeloperoxidase (MPO) is released during inflammation, producing reactive oxygen and nitrogen species.
  • MPO contributes to oxidative stress and inflammation, implicated in neurological disorders.

Purpose of the Study:

  • To review the pathophysiological roles of MPO.
  • To explore MPO as a therapeutic target and biomarker for neurological diseases.

Main Methods:

  • Literature review of MPO's function in inflammation and neurological conditions.
  • Analysis of MPO's involvement in oxidative stress and neuroinflammation.

Main Results:

  • MPO's dual role in pathogen defense and exacerbating inflammation/oxidative stress.
  • MPO's potential as a biomarker for risk stratification in neurological disorders.

Conclusions:

  • Targeting MPO presents a promising therapeutic avenue.
  • MPO can serve as a valuable biomarker for diagnosing and managing neurological disorders.
Keywords:
Myeloperoxidaseneuroinflammationneuroprotection

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