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Updated: Feb 15, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Vaccine resistant pseudorabies virus causes mink infection in China
Gui-Sheng Wang1,2, Yijun Du3, Jia-Qiang Wu3
1Shandong Provincial Center for Animal Disease Control and Prevention, Jinan, China.
Background:
Pseudorabies, a highly contagious infectious disease of swine is caused by pseudorabies virus (PRV). PRV can cause fatal infection in other animal species.
Results:
We report a deadly outbreak of pseudorabies that killed 87.2% (3522/4028) minks in a farm in 2014 in Shandong Province, China. PRV was isolated by using Vero cell culture and detected in mink samples by PCR from minks died during the outbreak. Epidemiological analysis indicated that 5.8% of minks (33/566) were PCR positive to PRV in Shandong Province. Phylogenetic analysis indicated that the PRV strains isolated from minks in this study were in the same clade with the Chinese porcine PRV isolates, which are resistant to the PRV vaccine.
Conclusions:
We demonstrated that pseudorabies virus caused an outbreak of minks in a farm in Shandong Province of China and the virus has a very high infection rate in minks in Shandong Province, which is a challenge for the fur industry in China.
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