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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

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Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant

Shiying Wang1, Suxia Yang1, Xinxin Zhao1

  • 1Department of Nephrology of Huaihe Hospital of Henan University, Henan Province, China.

Scientific Reports
|January 21, 2018
PubMed

Insights

Renal denervation (RDN) showed short-term cardiac improvements in resistant hypertension patients. However, RDN was not superior to intensive drug therapy in improving cardiac remodeling and function long-term.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Resistant hypertension (RH) poses significant cardiovascular risks.
  • Diastolic dysfunction is a common complication of hypertension.
  • Renal denervation (RDN) is an emerging therapy for RH.

Purpose of the Study:

  • To systematically evaluate RDN's impact on cardiac structure and function.
  • To compare RDN outcomes with pharmaceutical therapy in RH patients.
  • To assess changes in left ventricular mass (LVMI) and diastolic function (E/e').

Main Methods:

  • Systematic review and meta-analysis of retrieved studies.
  • Inclusion of randomized controlled trials (RCTs), controlled, and uncontrolled studies.
  • Data extraction on LVMI, E/e', left ventricular ejection fraction (LVEF), and N-terminal pro B-type natriuretic peptide (BNP).

Main Results:

  • Observational studies showed reduced LVMI, E/e', and BNP at 6 months post-RDN.
  • LV ejection fraction (LVEF) increased at 6 months in observational studies.
  • RCTs found no significant difference in LVMI, E/e', BNP, or LVEF at 12 months compared to optimal drug therapy.

Conclusions:

  • RDN demonstrated short-term improvements in left ventricular hypertrophy and cardiac function.
  • Current evidence does not support RDN's superiority over intensive drug therapy for cardiac remodeling.
  • Further research is needed to clarify RDN's long-term efficacy and role in managing resistant hypertension.

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