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4;11 translocation-associated acute leukemia: a comprehensive analysis.

M De Braekeleer, C C Lin

    Cancer Genetics and Cytogenetics
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    A girl with common acute lymphoblastic leukemia and the t(4;11) translocation achieved complete remission after chemotherapy. This rare leukemia subtype, often affecting children, is characterized by high white blood cell counts and historically short survival.

    Area of Science:

    • Hematology
    • Oncology
    • Genetics

    Background:

    • The t(4;11) translocation is a specific genetic abnormality found in certain types of acute leukemia.
    • Acute lymphoblastic leukemia (ALL) is a cancer of the blood and bone marrow.
    • The t(4;11) rearrangement is associated with a distinct subtype of ALL, often presenting with specific clinical and hematologic features.

    Purpose of the Study:

    • To present a case of common acute lymphoblastic leukemia associated with the t(4;11) translocation.
    • To contribute to the understanding of the clinical characteristics and outcomes of t(4;11)-associated acute leukemia.
    • To highlight the heterogeneity within this group of leukemias.

    Main Methods:

    • Case presentation of a pediatric patient with acute lymphoblastic leukemia.

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  • Physical examination findings including hepatosplenomegaly.
  • Hematologic analysis revealing a high white blood cell count.
  • Treatment with chemotherapy leading to complete remission.

    • Main Results:

    • The patient presented with common acute lymphoblastic leukemia and the t(4;11) translocation.
    • Physical examination revealed hepatosplenomegaly and hematologic analysis showed leukocytosis.
    • Chemotherapy resulted in a complete remission maintained for 8 months.
    • A review of published literature identified 43 cases of t(4;11)-associated acute leukemia.

    Conclusions:

    • The t(4;11)-associated acute leukemia, while rare, predominantly affects children and women.
    • This leukemia subtype is characterized by a high white blood cell count and a historically poor prognosis.
    • The t(4;11)-associated acute leukemia represents a heterogeneous group including various subtypes of ALL.