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Updated: Feb 15, 2026

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Published on: July 17, 2012
Dual energy computed tomography should be a first line preoperative localization imaging test for primary
Jake Hiebert1, Cameron Hague2, Shangmei Hou1
1Department of Surgery, St. Paul's Hospital & University of British Columbia, Vancouver, BC, Canada.
Background:
The objective of this study was to evaluate the performance of dual-energy computed tomography (DECT) for preoperative parathyroid tumor (PT) localization in primary hyperparathyroid (PHP) patients.
Methods:
A retrospective review was carried out of the medical records of all PHP patients who underwent ultrasound (US), Tc-99m sestamibi noncontrast single photon emission computed tomography (CT-MIBI), DECT and parathyroidectomy at a single center.
Results:
The sensitivities and accuracies for preoperative PT localization in the 97 patient study population were: US 40% and 93%, CT-MIBI 64.0% and 97%, and DECT 84% and 96%, respectively. In the one third of the study population that did not localize preoperatively with CT-MIBI and US, DECT correctly localized a PT in 21 cases (66%). DE-CT and US correctly localized a PT in 86% of cases, and only 5 (8%) of the cases that were accurately localized by a combination of CT-MIBI and US were not identified by DE-CT.
Conclusions:
DECT should be utilized as a first line preoperative PT localization study in PHP patients, and is also a sensitive salvage localization test.
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