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Updated: Feb 15, 2026

Using a Chemical Biopsy for Graft Quality Assessment
Published on: June 17, 2020
[Echographic diagnosis of missed early miscarriage: Assessment of image quality]
C Barthes1, C Mezan De Malartic2, C Baumann3
1Maternité du CHRU Nancy, 10, rue du Docteur-Heydenreich, 54000 Nancy, France; Université de Lorraine, 9, avenue de la Forêt-de-Haye, 54505 Vandœuvre-lès-Nancy, France.
Objective:
Ultrasound examination plays a central role in case of suspected non-viable pregnancy. A wrong diagnosis might have major consequence in terms of inadequate care, especially in cases of false positive non-viable pregnancy diagnosis. Ultrasound criterions are today well defined. Our objective was to evaluate the feasibility and reproducibility of a novel image-quoting method of first-trimester non-viable pregnancy.
Methods:
Thirty images of non-viable pregnancy were twice evaluated with blinded proofreading. Two quotations were evaluated: the first for the images of gestational sacs without embryo (gestational sac score), the second for the images with embryo (embryo score).
Results:
The ICC (interclass correlation coefficient) was>0.75 for inter- and intra-observer reproducibility both for the quotations of the gestational sac and for the embryo with a low variability. Reproducibility of quoting crown rump length measurements <5mm was low at first proofreading but after adjustment of the quoting modalities, ICC was also>0.75.
Conclusion:
The inter- and intra-observer reproducibility of our quoting methods is high with a low variability. They might be a useful tool in current practice in the future.
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