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Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
Published on: May 9, 2025
PEGylated chitosan nanoparticles with embedded bismuth sulfide for dual-wavelength fluorescent imaging and
Ke Wang1, Jialang Zhuang1, Yubing Liu1
1School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Abstract:
It is of great significance to construct multifunctional nanosystems for simultaneous imaging and therapy of cancer cells. Herein, PEGylated chitosan nanoparticles with embedded bismuth sulfide were facilely fabricated via reverse-microemulsion method for fluorescent imaging and photothermal therapy of HepG2 cells. The obtained BSA-Bi2S3-CG-PEG nanospheres revealed dual-wavelength fluorescence, which were spectrally isolated from the bioautofluorescence. Moreover, they demonstrated remarkable photothermal conversion efficiency and stability. Importantly, these small BSA-Bi2S3-CG-PEG nanoparticles shown a zeta potential of + 42.3 mV, which could rapidly get into HepG2 cells and locate in the cytoplasm and nuclei of cells. Based on their excellent photothermal effect and high cellular uptake, BSA-Bi2S3-CG-PEG nanoparticles could efficiently kill HepG2 cells under an 808 nm laser irradiation. This construction strategy can be used for preparation of fluorescent chitosan nanoparticles with other therapeutic agents embedded, which would provide a versatile platform for dual-wavelength fluorescent imaging guided therapy of cancer.
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