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Classification of heterogeneous genetic variations of microRNA regulome in cancer

Karin Hrovatin1, Tanja Kunej1

  • 1Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Slovenia.

Cancer Letters
|January 22, 2018
PubMed

Insights

Genetic variations in microRNA (miRNA) regulome impact cancer development. This study systematizes these variations and their role in cancer, aiding in developing new miRNA-based diagnostics and treatments.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNA (miRNA) regulome alterations are linked to cancer.
  • miRNAs regulate oncogenes and tumor suppressors, influencing cell transformation.
  • Understanding miRNA molecular changes is crucial for cancer diagnosis and treatment.

Purpose of the Study:

  • To classify genetic variations in the miRNA regulome associated with cancer.
  • To provide a systematic overview of miRNA regulome alterations.
  • To present miRNA-based diagnostic and treatment strategies.

Main Methods:

  • Classification of genetic variations including structural polymorphisms, short polymorphisms, and epigenetic changes.
  • Analysis of alterations affecting miRNA genes, regulatory elements, processing, degradation, and targets.
  • Review of existing literature on miRNA regulome variations in cancer.

Main Results:

  • Genetic variations in the miRNA regulome encompass structural and short polymorphisms, and epigenetic modifications.
  • These alterations impact miRNA silencing by affecting various components of the miRNA pathway.
  • Differential expression of miRNA regulome components is frequently observed in cancer.

Conclusions:

  • Systematic classification of miRNA regulome variations is essential for targeted research and understanding miRNA function in cancer.
  • Genetic variability and expression patterns of the miRNA regulome offer potential for novel cancer diagnostics and therapeutics.
Keywords:
BiomarkerCancer treatmentEpigenomicsSequence variantmiRNA silencingmicroRNA degradation

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