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Updated: Feb 11, 2026
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
Automated radiosynthesis of Al[18F]PSMA-11 for large scale routine use
Ken Kersemans1, Kathia De Man1, Jan Courtyn1
1Ghent University Hospital, Nuclear Medicine, De Pintelaan 185, Ghent, Belgium.
Objectives:
We report a reproducible automated radiosynthesis for large scale batch production of clinical grade Al[18F]PSMA-11.
Methods:
A SynthraFCHOL module was optimized to synthesize Al[18F]PSMA-11 by Al[18F]-chelation. Results Al[18F]PSMA-11 was synthesized within 35min in a yield of 21 ± 3% (24.0 ± 6.0GBq) and a radiochemical purity > 95%. Batches were stable for 4h and conform the European Pharmacopeia guidelines.
Conclusions:
The automated synthesis of Al[18F]PSMA-11 allows for large scale production and distribution of Al[18F]PSMA-11.
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