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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Peripheral Th17/Treg imbalance in elderly patients with ischemic stroke
Sanam Dolati1,2,3,4, Majid Ahmadi1,2, Mohammad Khalili5
1Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Summary
Immune responses involving regulatory T (Treg) and Th17 cells are critical in ischemic stroke (IS). This study found reduced Treg cells and increased Th17 cells in IS patients, suggesting a potential therapeutic target for IS.
Area of Science:
- Immunology
- Neuroscience
- Pathogenesis of Ischemic Stroke
Background:
- Regulatory T (Treg) and Th17 cells are crucial for peripheral immunity.
- Immune responses significantly contribute to the pathogenesis of ischemic stroke (IS).
- The specific roles of Th17 cells and the Treg/Th17 balance in IS remain unclear.
Purpose of the Study:
- To investigate the frequencies of Th17 and Treg cells in IS patients.
- To analyze the expression of related transcription factors and microRNAs.
- To compare these parameters between IS patients and healthy controls.
Main Methods:
- Flow cytometry was used to assess lymphocyte frequencies.
- Real-time PCR was employed to measure transcription factor and microRNA expression.
- Enzyme-linked immunosorbent assay (ELISA) quantified serum cytokine levels.
Main Results:
- IS patients showed a significant decrease in Treg cell proportion and lower TGF-β/FOXP3 expression.
- Th17 cell proportions and IL-17A/RORγt expression were markedly increased in IS patients.
- Levels of specific microRNAs (mir-326 and mir-106b-25) were elevated in IS patients.
Conclusions:
- An increased Th17/Treg cell ratio may contribute to the pathogenesis of ischemic stroke.
- Modulating the Treg/Th17 balance could offer a novel therapeutic strategy for IS.
- Further research into immune cell dynamics in IS is warranted.
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