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Hepatoprotective natural triterpenoids.

Guo-Bo Xu1, Yao-Hua Xiao2, Qing-Yan Zhang3

  • 1School of Pharmacy/State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, Guizhou, China; National Engineering Research Center of Miao's Medicines & Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education, Guiyang 550004, Guizhou, China; Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University, Guian New District, 550025, Guizhou, China.

European Journal of Medicinal Chemistry
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Natural triterpenoids show significant potential as hepatoprotective agents for liver diseases. This review covers 350 compounds and their structure-activity relationships, highlighting their value in drug discovery.

Keywords:
HepatoprotectiveNatural triterpenoids

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Hepatology

Background:

  • Liver diseases represent a major global health burden, driving the need for novel hepatoprotective agents.
  • Natural products, particularly triterpenoids, are recognized as promising sources for developing effective and safe liver-protective drugs.
  • Despite their potential, natural triterpenoids are often overlooked in hepatoprotective drug discovery reviews.

Purpose of the Study:

  • To comprehensively review natural triterpenoids with reported hepatoprotective effects.
  • To analyze structure-activity relationships of selected natural triterpenoids.
  • To underscore the importance of natural triterpenoids in the development of new hepatoprotective therapies.

Main Methods:

  • Systematic literature review of scientific publications from 1975 to 2016.
  • Inclusion of approximately 350 natural triterpenoids with documented hepatoprotective activities.
  • Exclusion of patent literature to focus on peer-reviewed research.

Main Results:

  • Identification of a substantial number of natural triterpenoids exhibiting hepatoprotective properties.
  • Discussion of structure-activity relationships for specific classes of triterpenoids, correlating chemical structure with biological effect.
  • Compilation of data from approximately 120 references, providing a broad overview of the field.

Conclusions:

  • Natural triterpenoids constitute a vital and underexplored resource for discovering novel hepatoprotective drugs.
  • Further research into the structure-activity relationships of these compounds can accelerate the development of effective liver disease treatments.
  • This review highlights the significant, yet underestimated, therapeutic potential of natural triterpenoids in combating liver diseases.