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Updated: Feb 15, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

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Published on: November 30, 2022

Recent Progress in Decarboxylative Oxidative Cross-Coupling for Biaryl Synthesis.

Gregory J P Perry¹, Igor Larrosa¹

¹School of Chemistry University of Manchester Oxford Road M13 9PL Manchester U.K.

European Journal of Organic Chemistry

|January 23, 2018

Summary

Benzoic acid derivatives are emerging as efficient and sustainable reagents for decarboxylative cross-coupling reactions. This microreview highlights recent advancements in coupling these compounds with arenes or other benzoic acids for atom-economic synthesis.

Keywords:

Biaryls Cross‐coupling C–H activation Decarboxylation Oxidative Coupling

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Published on: April 4, 2014

Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

The 21st century has witnessed significant advancements in decarboxylative activation strategies.
Benzoic acid derivatives offer sustainable, cost-effective, and stable alternatives to traditional cross-coupling reagents.

Purpose of the Study:

To review recent developments in the decarboxylative cross-coupling of benzoic acid derivatives.
To highlight the coupling of benzoic acids with arenes or other benzoic acids (decarboxylative oxidative cross-coupling).

Main Methods:

Review of literature on decarboxylative oxidative cross-coupling reactions.
Focus on methods utilizing benzoic acid derivatives as coupling partners.

Main Results:

Benzoic acid derivatives are effective in decarboxylative oxidative cross-coupling reactions.
These reactions enable the formation of new carbon-carbon bonds with high atom economy.

Conclusions:

Decarboxylative cross-coupling using benzoic acid derivatives represents a promising area in synthetic chemistry.
These methods facilitate the development of highly selective and atom-economic synthetic routes.