Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium and the kidney.

K J MacDonald, P J Little, R R Bailey

    The New Zealand Medical Journal
    |October 24, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Lithium carbonate treatment for manic-depressive illness can cause serious kidney problems, including permanent renal damage, even with normal serum lithium levels. Long-term lithium therapy poses significant risks to renal health.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sex hormones play a role in vulnerability to sleep loss on emotion processing tasks.

    Neurobiology of sleep and circadian rhythms·2019
    Same author

    Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling.

    British journal of pharmacology·2015
    Same author

    Variations in the MRI appearance of the insertion of the tendon of subscapularis.

    Clinical anatomy (New York, N.Y.)·2009
    Same author

    Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease.

    Cardiovascular research·2007
    Same author

    Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding.

    Diabetologia·2004
    Same author

    Preclinical studies of opioids and opioid antagonists on gastrointestinal function.

    Neurogastroenterology and motility·2004
    Same journal

    Reed diffusers: a potential cause of poisoning in young children in New Zealand.

    The New Zealand medical journal·2026
    Same journal

    Stuffy nights: elevated bedroom carbon dioxide concentrations indicate inadequate ventilation in Wellington homes.

    The New Zealand medical journal·2026
    Same journal

    Cautionary tale of how sodium polystyrene sulfonate caused gut necrosis: a case report.

    The New Zealand medical journal·2026
    Same journal

    Emergency lateral canthotomy and cantholysis for acute globe subluxation.

    The New Zealand medical journal·2026
    Same journal

    Liberation of an incarcerated tibialis posterior tendon following a posterior malleolar ankle fracture: a case report.

    The New Zealand medical journal·2026
    Same journal

    Implementing a cultural safety training plan across medical colleges in Aotearoa New Zealand-looking back, and looking forward.

    The New Zealand medical journal·2026
    See all related articles

    Area of Science:

    • Nephrology
    • Psychiatry
    • Pharmacology

    Background:

    • Lithium carbonate is a common treatment for manic-depressive illness (bipolar disorder).
    • Long-term lithium use is associated with various adverse effects.
    • Renal complications are a known concern with lithium therapy.

    Observation:

    • Three middle-aged women receiving lithium carbonate for manic-depressive illness developed kidney issues.
    • Complications included nephrogenic diabetes insipidus, renal tubular acidosis, and hypercalcemia-associated acute renal impairment.
    • One patient experienced irreversible chronic renal damage.

    Findings:

    • Renal toxicity occurred despite normal serum lithium concentrations.
    • The severity of renal damage varied among the patients.

    Related Experiment Videos

  • These cases highlight potential nephrotoxicity even within therapeutic lithium ranges.

    • Implications:

    • Clinicians must carefully monitor renal function in patients on long-term lithium therapy.
    • The risk of irreversible kidney damage necessitates cautious prescribing and patient education.
    • Further research is needed to understand the mechanisms of lithium-induced nephrotoxicity and develop safer treatment strategies.