Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

445
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
445
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

345
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
345
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

268
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
268
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

5.6K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
5.6K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

335
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
335
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

280
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
280

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of advanced training skills among GPs: a systematic review.

Rural and remote health·2026
Same author

Operationalising readiness for practice in final OSCEs: insights from a mixed-methods study across five Australian medical schools.

BMC medical education·2026
Same author

Pharmacists' professional and service qualifications for the care of Trans, Travesti, and Gender-Diverse people in southern Brazil: a grounded theory study.

Frontiers in medicine·2026
Same author

Assessing the Utility of AI Versus Human-Created MCQs in Pediatric Medical Education.

Journal of medical education and curricular development·2026
Same author

Turning struggles into strengths: A qualitative exploration of academic difficulty in medical school.

Medical teacher·2026
Same author

The ADAPT model: integrating employer insights into a framework for practice-ready health professions graduates.

BMC medical education·2026

Related Experiment Video

Updated: Feb 15, 2026

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells
07:21

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells

Published on: September 17, 2021

4.1K

Addressing varenicline adherence through repackaging in a dose administration aid.

Aaron D Drovandi1, Sherryl G Robertson1, Bunmi S Malau-Aduli1

  • 1College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.

Integrated Pharmacy Research & Practice
|January 23, 2018
PubMed
Summary

Repackaging varenicline tartrate tablets into dose administration aids is suitable for improving adherence and smoking cessation rates. The stability of varenicline tartrate tablets is maintained after repackaging under ambient conditions.

Keywords:
compliancedegradationstability

More Related Videos

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
09:20

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

Published on: July 23, 2010

16.4K
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.8K

Related Experiment Videos

Last Updated: Feb 15, 2026

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells
07:21

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells

Published on: September 17, 2021

4.1K
In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
09:20

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

Published on: July 23, 2010

16.4K
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.8K

Area of Science:

  • Pharmaceutical science
  • Drug stability and formulation

Background:

  • Medication adherence is crucial for smoking cessation success.
  • Non-adherence to varenicline (Champix®) reduces smoking abstinence rates.
  • Dose administration aids may improve adherence, but medication stability post-repackaging is often unconfirmed.

Purpose of the Study:

  • To assess the physical and chemical stability of varenicline tartrate tablets after repackaging into dose administration aids.
  • To determine the suitability of repackaged varenicline for storage under ambient conditions for 6 weeks.

Main Methods:

  • Varenicline tartrate 1.0 mg tablets were repackaged into blister compartments.
  • Tablets were stored for 42 days at 30°C/75% RH (WHO Zone IVB conditions).
  • Physical tests (thickness, hardness, weight uniformity, friability, dissolution, disintegration) and chemical tests (content uniformity) were performed.

Main Results:

  • Tablet weight, friability, and thickness met compendial standards.
  • Varenicline content remained within 95%-105% after exposure to light and storage.
  • Tablet hardness and disintegration rates decreased over the storage period.

Conclusions:

  • Repackaging varenicline tartrate tablets into dose administration aids is feasible.
  • This practice can enhance adherence and smoking abstinence rates.
  • Repackaging does not compromise the physical or chemical stability of the tablets.