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Platelet-activating factor receptor affects food intake and body weight
Wei Li1,2, Thomas M McIntyre1,2
1Departments of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, USA.
Genes & Diseases
|January 23, 2018
Summary
The platelet-activating factor receptor (PTAFR) influences behaviors linked to childhood obesity. Ablating PTAFR increased weight gain by raising food intake and reducing movement in mice.
Area of Science:
- Molecular Biology
- Physiology
- Behavioral Science
Background:
- Childhood obesity is a growing public health concern.
- The molecular mechanisms underlying obesity-related behavioral changes are not fully understood.
Purpose of the Study:
- To investigate the role of the platelet-activating factor receptor (PTAFR) in regulating behaviors associated with obesity.
- To explore the impact of PTAFR on metabolic and physical activity in mice.
Main Methods:
- Continuous monitoring of mouse body weight.
- Assessment of metabolic, physical activity, and food intake behaviors using a Comprehensive Lab Animal Monitoring System (CLAMS).
- Comparison between wild-type and Ptafr knockout (Ptafr-/-) mice fed standard chow and high-fat Western diets.
Main Results:
- Ptafr ablation significantly increased weight gain in mice without altering adipose tissue accumulation.
- Mice lacking PTAFR exhibited increased food intake and decreased physical activity.
- PTAFR did not affect the metabolism of dietary fat and carbohydrates in young animals.
Conclusions:
- The platelet-activating factor receptor (PTAFR) plays a critical role in modifying life behaviors relevant to obesity.
- Targeting PTAFR activity presents a potential novel strategy for controlling obesity in children and young adults.
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